Academic staff
Dr Valentina Caputo Galarce
caputogv@lsbu.ac.uk
Human Sciences
https://orcid.org/0000-0002-4011-5238 (unauthenticated)
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I am a Senior Lecturer in Biomedical Science. I joined LSBU in November 2021 from Imperial College London.
I received my PhD in Molecular Genetics and Biotechnology in 2003 at the OP jointly with I.C.G.E.B. Trieste, Italy, Before that I did a BSc and Masters in Biochemistry in the 'Pontificia Universidad Católica de Chile (PUC) Santiago, Chile, my country of origin.
Currently I'm a member of several professional bodies including:
The British Society for Haematology (BSH), European Hematology Association (EHA), European Association of Cancer Research (EACR-EACR26587) and American Society of Cancer Research (AACR Member ID: 1074104)
My main research focus is in regulatory genomics in Multiple Myeloma. I'm passionate about development and application of genetic and epigenetic tools to study the molecular mechanisms that underpin normal and malignant differentiation and development, in particular in haematological malignancies.
Courses taught
Biomedical Sciences - BSc (Hons)
BSc (Hons) Bioscience 2022/23
Postgraduate Research Supervision
Current
| Mrs Mavra Manzar | Significance of the nuclear Insulin-like Growth Factor Receptor-1 in Liver Cancer". | PhD |
| Mrs Iyabosola Miedzianowska | Doctoral Research Project | PhD |
| Miss Iman Hikmat Majeed Albu-Rghaif | Doctoral Research Project | PhD |
Awarded in the last 5 years
| Dr N Trasanidis | PhD | |
| Dr A. Kasarou, MD | PhD | |
| Mr. S Okoli, MD | PhD |
Open University jointly with I.C.G.E.B. Trieste, Italy.
Pontificia Universidad Católica de Chile (PUC). Santiago, Chile.
Pontificia Universidad Católica de Chile (PUC). Santiago, Chile.
Research
Supervision (MSc, PhD, BSC)
Teaching
Research
Supervision (MSc, PhD, BSc)
Teaching
Research
Supervision (MSc, BSc)
| Funder | Year won | Project | Role |
|---|---|---|---|
| European Hematology Association | 2024 | EHA Mobility Grant | Principal Investigator |
| Proposal | Project | Role | Funder | Status | Status last updated |
|---|---|---|---|---|---|
| Regulatory genomics in Multiple Myeloma: translating basic biology to clinical diagnostic and therapeutic applications | Molecular Validation of Myeloma Enhancers | Principal Investigator | Leukemia & Lymphoma Society (LLS) | OPEN In preparation | Aug 2024 |
Special Issue "Advances and Applications of Regulatory Genomics in Multiple Myeloma"
Honorary Research Fellow| Hugh & Josseline Langmuir Centre for Myeloma Research| Centre for Haematology| Department of Immunology and Inflammation |
Multiple Myeloma
Epigenetics
Gene regulation
Research collaborator to Dr. Monika Holubova
AML
single cell transcriptomics
PhD External Examiner
PhD External Examiner
NK Differentiation project collaboration
Professor Hugh JM Brady
Faculty of Natural Sciences, Department of Life Sciences
single cell transcriptomics- Summer School
Main supervisor
School on 2020 and 2022
https://singlecell-pilsen2022.zcu.cz/
Research collaboration on regulatory genomics. Machine learning
Dr Chinedu Anthony Anene
Senior Lecturer in Bioinformatics
School of Health, Leeds Beckett University
|
Honorary Lecturer in Bioinformatics
Centre for Cancer Genomics and Computational Biology
CRUK BARTS Centre, Queen Mary University of London
Collaboration with Antonia Rotolo MD PhD on molecular mechanism of CAR-iNKT therapy
Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Collaboration with:
Aleksander Jankowski, Ph.D.
Faculty of Mathematics, Informatics and Mechanics
University of Warsaw
Subject: single cell iNKT differentiation in vito
Reach and Impact
Jul 2007 - Aug 2009
2007 and 2009:
Summer Courses
Laboratory Assistant, Eukaryotic Gene Expression course. Cold Spring Harbor Laboratory (CSHL). July-August 2007 and 2009.
MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis
Katsarou, A., Trasanidis, N., Ponnusamy, K., Kostopoulos, I., Alvarez-Benayas, J., Papaleonidopoulou, F., Keren, K., Sabbattini, P.M. R., Feldhahn, N., Papaioannou, M., Hatjiharissi, E., Sudbery, I., Chaidos, A., Caputo, V. and Karadimitris, A. (2023). MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis. Blood Advances. 7 (21), pp. 6395-6410. https://doi.org/10.1182/bloodadvances.2023009772
Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma
Trasanidis, N., Katsarou, A., Ponnusamy, K., Shen, Y.A., Kostopoulos, I.V., Bergonia, B., Keren, K., Reema, P., Xiao, X., Szydlo, R. M., Sabbattini, P., Roberts, I., Auner, H., Naresh, K., Chaidos, A., Wang, T.L., Magnani, L., Caputo, V. and Karadimitris, A. (2022). Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma. Blood. https://doi.org/10.1182/blood.2021014391
Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
Alvarez-Benayas, J., Trasanidis, N., Katsarou, A., Ponnusamy, K., Chaidos, A., May, P.C., Xiao, X., Bua, M., Atta, M., Roberts, I., Auner, H.W., Hatjiharissi, E., Papaioannou, M., Caputo Galarce, V., Sudbery, I.M. and Karadimitris, A. (2021). Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma. Nature Communications. 12, p. 5450. https://doi.org/10.1038/s41467-021-25704-2
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
Iskander, D., Wang,G., Heuston, E.F., Christodoulidou, C., Psaila, B., Ponnusamy, K., Ren, H., Mokhtari, Z., Robinson, M., Chaidos, A., Trivedi, P., Trasanidis, N., Katsarou, A., Szydlo, R., NISC Comparative Sequencing Program, Palii, C.G., Ziadi, Z., Al-Oqaily, Q., Caputo Galarce, V., Roy, A., Harrington, Y., Karnik, L., Naresh, K., Mead,A.J., Thongjuea, S., Brand, M., de la Fuente, J., Bodine, D.M., Roberts,I. and Karadimitris, A. (2021). Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 13 (610). https://doi.org/10.1126/scitranslmed.abf0113
Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs
Saavedra-Garcia, P., Roman-Trufero, M., Al-Sadah, H.A., Blighe, K., Lopez-Jimenez, E., Christoforou, M., Penfold, L., Capece, D., Xiong, X., Miao, Y., Parzych, K., Caputo, V., Siskos, A.P., Encheva, V., Liu, Z., Thiel, D., Kaiser, M.F., Piazza, P., Chaidos, A., Karadimitris, A., Franzoso, G., Snijders, A.P., Keun, H.C., Oyarzun, D.A., Barahona, M. and Auner, H.W. (2021). Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs. PNAS. 118 (17), p. e2018229118. https://doi.org/10.1073/pnas.2018229118
Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation
Machuldova, A., Holubova, M., Caputo, V.S., Cedikova, M., Jindra, P., Houdova, L. and Pitule, P. (2021). Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation. Frontiers in Immunology. 12, p. 651751. https://doi.org/10.3389/fimmu.2021.651751
The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma
Ponnusamy, K., Tzioni, M. M., Begum, M., Robinson, M. E., Caputo, V., Katsarou, A., Trasanidis, N., Xiao, X., Kostopoulos, I. V., Iskander, D., Roberts, I., Trivedi, P., Auner, H. W., Naresh, K., Chaidos, A. and Karadimitris, A. (2021). The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. Haematologica. https://doi.org/10.3324/haematol.2020.274480
Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro
Caputo Galarce, V., Trasanidis, N., Xiao, X., Robinson, M. E., Katsarou, A., Ponnusamy, K., Prinjha, R. K., Smithers, N., Chaidos, A., Auner, H. W. and Karadimitris, A. (2021). Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro. iScience. 24 (1), pp. 101989-101989. https://doi.org/10.1016/j.isci.2020.101989
Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report
Ostasov, P., Robertson, H., Piazza, P., Datta, A., Apperley, J., Houdova, L., Lysak, D., Holubova, M., Tesarova, K., Caputo Galarce, V. and Barrozzi, I. (2020). Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report. Frontiers in Oncology. 10, p. 2356. https://doi.org/10.3389/fonc.2020.584607
Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study
Dekojová T., Houdová, L., Fatka, J., Pitule, P., Ostašov, P., Gmucová, H., Lysák, D., Jindra, P., Holubová, M. and Caputo Galarce, V. (2020). Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study. Journal of Clinical Medicine. 9 (11), p. 3502. https://doi.org/10.3390/jcm9113502
Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells
Holubova, M., Leba, M., Gmucova, H., Caputo Galarce, V., Jindra, P. and Lysak, D. (2019). Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells. International Journal of Molecular Sciences. 20 (14), p. 3472. https://doi.org/10.3390/ijms20143472
The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
Parzych, K., Saavedra-García, P., Valbuena, G.N., Al-Sadah, H.A., Robinson, M.E., Penfold, L., Kuzeva, D.M., Ruiz-Tellez, A,, Loaiza, S,, Holzmann, V., Caputo Galarce, V., Johnson, D.C., Kaiser, M.F., Karadimitris, A,, Lam, E.W.F, Chevet, E., Feldhahn, N., Keun, H.C. and Auner, H.W. (2019). The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. Oncogene. 38, p. 3216–3231. https://doi.org/10.1038/s41388-018-0651-z
Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
Rotolo, A., Caputo Galarce, V., Holubova, M., Baxan, N., Dubois, O., Chaudhry, M.S., Xiao, X., Goudevenou, K., Pitcher, D.S., Petevi, K., Kachramanoglou, C., Iles, S., Naresh, K., Maher, J. and Karadimitris, A. (2018). Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting. Cancer Cell. 34 (4), pp. 596-610. https://doi.org/10.1016/j.ccell.2018.08.017
Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Psaila, B., Barkas, N., Iskander, D., Roy, A., Anderson, S., Ashley, N., Caputo Galarce, V., Lichtenberg, J., Loaiza, S., Bodine, D.M., Karadimitris, A., Mead, A.J. and Roberts, I. (2016). Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways. Genome Biology. 17 (1). https://doi.org/10.1186/s13059-016-0939-7