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HomeAcademic staffDr Valentina Caputo Galarce
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I am a Senior Lecturer in Biomedical Science. I joined LSBU in November 2021 from Imperial College London.

I received my PhD in Molecular Genetics and Biotechnology in 2003 at the OP jointly with I.C.G.E.B. Trieste, Italy, Before that I did a BSc and Masters in Biochemistry in the 'Pontificia Universidad Católica de Chile (PUC) Santiago, Chile, my country of origin.

Currently I'm a member of several professional bodies including:

The British Society for Haematology (BSH), European Hematology Association (EHA), European Association of Cancer Research (EACR-EACR26587) and American Society of Cancer Research (AACR Member ID: 1074104)

My main research focus is in regulatory genomics in Multiple Myeloma. I'm passionate about development and application of genetic and epigenetic tools to study the molecular mechanisms that underpin normal and malignant differentiation and development, in particular in haematological malignancies.

Courses taught

Biomedical Sciences - BSc (Hons)

BSc (Hons) Bioscience 2022/23

Postgraduate Research Supervision
Current
Mrs Mavra ManzarDoctoral Research ProjectPhD
Mrs Iyabosola MiedzianowskaDoctoral Research ProjectPhD
Miss Iman Hikmat Majeed Albu-RghaifDoctoral Research ProjectPhD
Mr. S Okoli, MDPhD

Awarded in the last 5 years
Dr N TrasanidisPhD
Dr A. Kasarou, MDPhD
PhD in Molecular Genetics and Biotechnology

Open University jointly with I.C.G.E.B. Trieste, Italy.

1999
2003
MSc in Biochemistry

Pontificia Universidad Católica de Chile (PUC). Santiago, Chile.

1995
1998
BSc in Biochemistry

Pontificia Universidad Católica de Chile (PUC). Santiago, Chile.

1991
1995
Research Fellow
Imperial College London

Research

Supervision (MSc, PhD, BSC)

Teaching

2017
2020
Education
Research Associates
Imperial Collage London

Research

Supervision (MSc, PhD, BSc)

Teaching

2009
2017
Education
Research Associate
Marie Curie Research Institute, Oxted UK

Research

Supervision (MSc, BSc)

2009
2003
Third sector/charities
The British Society for Haematology
2017
• European Hematology Association
2018
European Association of Cancer Research (EACR-EACR26587)
2018
American Society of Cancer Research (AACR Member ID: 1074104)
2019
https://www.mdpi.com/journal/biomedicines/special_issues/Y26C8EJAX9

Special Issue "Advances and Applications of Regulatory Genomics in Multiple Myeloma"

Guest editor
2023
2024
Potential Prognostic Markers for Relapsed/Refractory vs. Re-2 sponsive Acute Myeloid Leukemia
Meta-Analytic Comparison of Global RNA Transcriptomes of 2 Acute and Chronic Myeloid Leukemia Cells Reveals Novel 3 Gene Candidates Governing Myeloid Malignancies
Natural Killer Cells: A Promising Kit in the Adoptive Cell 2 Therapy Toolbox
Single-cell transcriptome profiling reveals the key role of ZNF683 in NK cell exhaustion in multiple myeloma
m5C Regulator-Mediated Methylation Modification Clusters Contribute to the Immune Microenvironment Regulation of Multiple Myeloma
Mitochondrial metabolic determinants of multiple myeloma growth, survival, and therapy efficacy
Development and Characterization of Three Cell Culture Systems to Investigate the Relationship between Primary Bone Marrow Adipocytes and Myeloma Cells
Pan-cancer analysis of the expression pattern of ZBP1, a regulator of PANoptosis
Bone Marrow Stromal Cell Induced Chromatin 1 Remodeling and Associated 2 Transcriptional Changes in Multiple Myeloma
Comisión Sectorial de Investigación Científica (CSIC) - URUGUAY
2022
Imperial College London
Honorary research fellow

Honorary Research Fellow| Hugh & Josseline Langmuir Centre for Myeloma Research| Centre for Haematology| Department of Immunology and Inflammation |

Multiple Myeloma

Epigenetics

Gene regulation

November 2020
Charles University in Prague
Visiting researcher

Research collaborator to Dr. Monika Holubova

AML

single cell transcriptomics

November 2019
University of Millan
External examiner

PhD External Examiner

PhD External Examiner

October 2021
Imperial College London, Faculty of Natural Sciences, Department of Life Sciences. UK

NK Differentiation project collaboration

Professor Hugh JM Brady

Faculty of Natural Sciences, Department of Life Sciences

October 2022
Charles University and 4EU+ Universitieas

single cell transcriptomics- Summer School

Main supervisor

School on 2020 and 2022

https://singlecell-pilsen2022.zcu.cz/

September 2020
Leeds Beckett University, School of Health. UK

Research collaboration on regulatory genomics. Machine learning

Dr Chinedu Anthony Anene

Senior Lecturer in Bioinformatics

School of Health, Leeds Beckett University

|

Honorary Lecturer in Bioinformatics

Centre for Cancer Genomics and Computational Biology

CRUK BARTS Centre, Queen Mary University of London

February 2033
University of Pennsylvania, USA

Collaboration with Antonia Rotolo MD PhD on molecular mechanism of CAR-iNKT therapy

Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Third sector
October 2022
University of Warsaw, Poland

Collaboration with:

Aleksander Jankowski, Ph.D.

Faculty of Mathematics, Informatics and Mechanics

University of Warsaw

Subject: single cell iNKT differentiation in vito

Third sector
September 2022
Reach and Impact

Jul 2007 - Aug 2009

2007 and 2009:

Summer Courses

Laboratory Assistant, Eukaryotic Gene Expression course. Cold Spring Harbor Laboratory (CSHL). July-August 2007 and 2009.


Filter publications

MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis
Katsarou, A., Trasanidis, N., Ponnusamy, K., Kostopoulos, I., Alvarez-Benayas, J., Papaleonidopoulou, F., Keren, K., Sabbattini, P.M. R., Feldhahn, N., Papaioannou, M., Hatjiharissi, E., Sudbery, I., Chaidos, A., Caputo, V. and Karadimitris, A. (2023). MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis. Blood Advances. 7 (21), pp. 6395-6410. https://doi.org/10.1182/bloodadvances.2023009772

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma
Trasanidis, N., Katsarou, A., Ponnusamy, K., Shen, Y.A., Kostopoulos, I.V., Bergonia, B., Keren, K., Reema, P., Xiao, X., Szydlo, R. M., Sabbattini, P., Roberts, I., Auner, H., Naresh, K., Chaidos, A., Wang, T.L., Magnani, L., Caputo, V. and Karadimitris, A. (2022). Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma. Blood. https://doi.org/10.1182/blood.2021014391

Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma
Alvarez-Benayas, J., Trasanidis, N., Katsarou, A., Ponnusamy, K., Chaidos, A., May, P.C., Xiao, X., Bua, M., Atta, M., Roberts, I., Auner, H.W., Hatjiharissi, E., Papaioannou, M., Caputo Galarce, V., Sudbery, I.M. and Karadimitris, A. (2021). Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma. Nature Communications. 12, p. 5450. https://doi.org/10.1038/s41467-021-25704-2

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
Iskander, D., Wang,G., Heuston, E.F., Christodoulidou, C., Psaila, B., Ponnusamy, K., Ren, H., Mokhtari, Z., Robinson, M., Chaidos, A., Trivedi, P., Trasanidis, N., Katsarou, A., Szydlo, R., NISC Comparative Sequencing Program, Palii, C.G., Ziadi, Z., Al-Oqaily, Q., Caputo Galarce, V., Roy, A., Harrington, Y., Karnik, L., Naresh, K., Mead,A.J., Thongjuea, S., Brand, M., de la Fuente, J., Bodine, D.M., Roberts,I. and Karadimitris, A. (2021). Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 13 (610). https://doi.org/10.1126/scitranslmed.abf0113

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs
Saavedra-Garcia, P., Roman-Trufero, M., Al-Sadah, H.A., Blighe, K., Lopez-Jimenez, E., Christoforou, M., Penfold, L., Capece, D., Xiong, X., Miao, Y., Parzych, K., Caputo, V., Siskos, A.P., Encheva, V., Liu, Z., Thiel, D., Kaiser, M.F., Piazza, P., Chaidos, A., Karadimitris, A., Franzoso, G., Snijders, A.P., Keun, H.C., Oyarzun, D.A., Barahona, M. and Auner, H.W. (2021). Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs. PNAS. 118 (17), p. e2018229118. https://doi.org/10.1073/pnas.2018229118

Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation
Machuldova, A., Holubova, M., Caputo, V.S., Cedikova, M., Jindra, P., Houdova, L. and Pitule, P. (2021). Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation. Frontiers in Immunology. 12, p. 651751. https://doi.org/10.3389/fimmu.2021.651751

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma
Ponnusamy, K., Tzioni, M. M., Begum, M., Robinson, M. E., Caputo, V., Katsarou, A., Trasanidis, N., Xiao, X., Kostopoulos, I. V., Iskander, D., Roberts, I., Trivedi, P., Auner, H. W., Naresh, K., Chaidos, A. and Karadimitris, A. (2021). The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. Haematologica. https://doi.org/10.3324/haematol.2020.274480

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro
Caputo Galarce, V., Trasanidis, N., Xiao, X., Robinson, M. E., Katsarou, A., Ponnusamy, K., Prinjha, R. K., Smithers, N., Chaidos, A., Auner, H. W. and Karadimitris, A. (2021). Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro. iScience. 24 (1), pp. 101989-101989. https://doi.org/10.1016/j.isci.2020.101989

Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report
Ostasov, P., Robertson, H., Piazza, P., Datta, A., Apperley, J., Houdova, L., Lysak, D., Holubova, M., Tesarova, K., Caputo Galarce, V. and Barrozzi, I. (2020). Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report. Frontiers in Oncology. 10, p. 2356. https://doi.org/10.3389/fonc.2020.584607

Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study
Dekojová T., Houdová, L., Fatka, J., Pitule, P., Ostašov, P., Gmucová, H., Lysák, D., Jindra, P., Holubová, M. and Caputo Galarce, V. (2020). Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study. Journal of Clinical Medicine. 9 (11), p. 3502. https://doi.org/10.3390/jcm9113502

Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells
Holubova, M., Leba, M., Gmucova, H., Caputo Galarce, V., Jindra, P. and Lysak, D. (2019). Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells. International Journal of Molecular Sciences. 20 (14), p. 3472. https://doi.org/10.3390/ijms20143472

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
Parzych, K., Saavedra-García, P., Valbuena, G.N., Al-Sadah, H.A., Robinson, M.E., Penfold, L., Kuzeva, D.M., Ruiz-Tellez, A,, Loaiza, S,, Holzmann, V., Caputo Galarce, V., Johnson, D.C., Kaiser, M.F., Karadimitris, A,, Lam, E.W.F, Chevet, E., Feldhahn, N., Keun, H.C. and Auner, H.W. (2019). The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. Oncogene. 38, p. 3216–3231. https://doi.org/10.1038/s41388-018-0651-z

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
Rotolo, A., Caputo Galarce, V., Holubova, M., Baxan, N., Dubois, O., Chaudhry, M.S., Xiao, X., Goudevenou, K., Pitcher, D.S., Petevi, K., Kachramanoglou, C., Iles, S., Naresh, K., Maher, J. and Karadimitris, A. (2018). Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting. Cancer Cell. 34 (4), pp. 596-610. https://doi.org/10.1016/j.ccell.2018.08.017

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Psaila, B., Barkas, N., Iskander, D., Roy, A., Anderson, S., Ashley, N., Caputo Galarce, V., Lichtenberg, J., Loaiza, S., Bodine, D.M., Karadimitris, A., Mead, A.J. and Roberts, I. (2016). Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways. Genome Biology. 17 (1). https://doi.org/10.1186/s13059-016-0939-7