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HomeAcademic staffDr Valentina Caputo Galarce
Dr Valentina Caputo Galarce

Dr Valentina Caputo Galarce

caputogv@lsbu.ac.uk

Human Sciences

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I am a Senior Lecturer in Biomedical Science. I joined LSBU in November 2021 from Imperial College London.

I received my PhD in Molecular Genetics and Biotechnology in 2003 at the OP jointly with I.C.G.E.B. Trieste, Italy, Before that I did a BSc and Masters in Biochemistry in the 'Pontificia Universidad Católica de Chile (PUC) Santiago, Chile, my country of origin.

Currently I'm a member of several professional bodies including:

The British Society for Haematology (BSH), European Hematology Association (EHA), European Association of Cancer Research (EACR-EACR26587) and American Society of Cancer Research (AACR Member ID: 1074104)

My main research focus is in regulatory genomics in Multiple Myeloma. I'm passionate about development and application of genetic and epigenetic tools to study the molecular mechanisms that underpin normal and malignant differentiation and development, in particular in haematological malignancies.

Courses taught

Biomedical Sciences - BSc (Hons)

BSc (Hons) Bioscience 2022/23

Postgraduate Research Supervision
Current
Mrs Mavra ManzarDoctoral Research ProjectPhD
Miss Banu Baarthi GodfriDoctoral Research ProjectPhD
Imperial College London
Honorary research fellow

Honorary Research Fellow| Hugh & Josseline Langmuir Centre for Myeloma Research| Centre for Haematology| Department of Immunology and Inflammation |

Multiple Myeloma

Epigenetics

Gene regulation

November 2020
Charles University in Prague
Other

Research collaborator to Dr. Monika Holubova

AML

single cell transcriptomics

November 2019

Filter publications

Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma
Trasanidis, N., Katsarou, A., Ponnusamy, K., Shen, Y.A., Kostopoulos, I.V., Bergonia, B., Keren, K., Reema, P., Xiao, X., Szydlo, R. M., Sabbattini, P., Roberts, I., Auner, H., Naresh, K., Chaidos, A., Wang, T.L., Magnani, L., Caputo, V. and Karadimitris, A. (2022). Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma. Blood. https://doi.org/10.1182/blood.2021014391

Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
Iskander, D., Wang,G., Heuston, E.F., Christodoulidou, C., Psaila, B., Ponnusamy, K., Ren, H., Mokhtari, Z., Robinson, M., Chaidos, A., Trivedi, P., Trasanidis, N., Katsarou, A., Szydlo, R., NISC Comparative Sequencing Program, Palii, C.G., Ziadi, Z., Al-Oqaily, Q., Caputo Galarce, V., Roy, A., Harrington, Y., Karnik, L., Naresh, K., Mead,A.J., Thongjuea, S., Brand, M., de la Fuente, J., Bodine, D.M., Roberts,I. and Karadimitris, A. (2021). Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia. Science Translational Medicine. 13 (610). https://doi.org/10.1126/scitranslmed.abf0113

Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs
Saavedra-Garcia, P., Roman-Trufero, M., Al-Sadah, H.A., Blighe, K., Lopez-Jimenez, E., Christoforou, M., Penfold, L., Capece, D., Xiong, X., Miao, Y., Parzych, K., Caputo, V., Siskos, A.P., Encheva, V., Liu, Z., Thiel, D., Kaiser, M.F., Piazza, P., Chaidos, A., Karadimitris, A., Franzoso, G., Snijders, A.P., Keun, H.C., Oyarzun, D.A., Barahona, M. and Auner, H.W. (2021). Systems level profiling of chemotherapy-induced stress resolution in cancer cells reveals druggable trade-offs. PNAS. 118 (17), p. e2018229118. https://doi.org/10.1073/pnas.2018229118

Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation
Machuldova, A., Holubova, M., Caputo, V.S., Cedikova, M., Jindra, P., Houdova, L. and Pitule, P. (2021). Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation. Frontiers in Immunology. 12, p. 651751. https://doi.org/10.3389/fimmu.2021.651751

The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma
Ponnusamy, K., Tzioni, M. M., Begum, M., Robinson, M. E., Caputo, V., Katsarou, A., Trasanidis, N., Xiao, X., Kostopoulos, I. V., Iskander, D., Roberts, I., Trivedi, P., Auner, H. W., Naresh, K., Chaidos, A. and Karadimitris, A. (2021). The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. Haematologica. https://doi.org/10.3324/haematol.2020.274480

Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro
Caputo Galarce, V., Trasanidis, N., Xiao, X., Robinson, M. E., Katsarou, A., Ponnusamy, K., Prinjha, R. K., Smithers, N., Chaidos, A., Auner, H. W. and Karadimitris, A. (2021). Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro. iScience. 24 (1), pp. 101989-101989. https://doi.org/10.1016/j.isci.2020.101989

Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report
Ostasov, P., Robertson, H., Piazza, P., Datta, A., Apperley, J., Houdova, L., Lysak, D., Holubova, M., Tesarova, K., Caputo Galarce, V. and Barrozzi, I. (2020). Evolution of Advanced Chronic Lymphoid Leukemia Unveiled by Single-Cell Transcriptomics: A Case Report. Frontiers in Oncology. 10, p. 2356. https://doi.org/10.3389/fonc.2020.584607

Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study
Dekojová T., Houdová, L., Fatka, J., Pitule, P., Ostašov, P., Gmucová, H., Lysák, D., Jindra, P., Holubová, M. and Caputo Galarce, V. (2020). Dynamic Changes of Inhibitory Killer-Immunoglobulin-Like Receptors on NK Cells after Allogeneic Hematopoietic Stem Cell Transplantation: An Initial Study. Journal of Clinical Medicine. 9 (11), p. 3502. https://doi.org/10.3390/jcm9113502

Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells
Holubova, M., Leba, M., Gmucova, H., Caputo Galarce, V., Jindra, P. and Lysak, D. (2019). Improving the Clinical Application of Natural Killer Cells by Modulating Signals Signal from Target Cells. International Journal of Molecular Sciences. 20 (14), p. 3472. https://doi.org/10.3390/ijms20143472

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation
Parzych, K., Saavedra-García, P., Valbuena, G.N., Al-Sadah, H.A., Robinson, M.E., Penfold, L., Kuzeva, D.M., Ruiz-Tellez, A,, Loaiza, S,, Holzmann, V., Caputo Galarce, V., Johnson, D.C., Kaiser, M.F., Karadimitris, A,, Lam, E.W.F, Chevet, E., Feldhahn, N., Keun, H.C. and Auner, H.W. (2019). The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. Oncogene. 38, p. 3216–3231. https://doi.org/10.1038/s41388-018-0651-z

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
Rotolo, A., Caputo Galarce, V., Holubova, M., Baxan, N., Dubois, O., Chaudhry, M.S., Xiao, X., Goudevenou, K., Pitcher, D.S., Petevi, K., Kachramanoglou, C., Iles, S., Naresh, K., Maher, J. and Karadimitris, A. (2018). Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting. Cancer Cell. 34 (4), pp. 596-610. https://doi.org/10.1016/j.ccell.2018.08.017

Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
Psaila, B., Barkas, N., Iskander, D., Roy, A., Anderson, S., Ashley, N., Caputo Galarce, V., Lichtenberg, J., Loaiza, S., Bodine, D.M., Karadimitris, A., Mead, A.J. and Roberts, I. (2016). Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways. Genome Biology. 17 (1). https://doi.org/10.1186/s13059-016-0939-7